Germline CDKN2A mutations are an established risk factor among melanoma-prone families. An accurate carrier probability model for CDKN2A can greatly facilitate genetic counseling for all members of hereditary melanoma families.
MelaPRO is a statistical model, with associated software, for assessing the probability than an individual carries a germline deleterious mutation of CDKN2A (p16), based on family history of single primary and multiple primary melanomas. It provides three separate prediction modules, based on penetrances previously estimated from 1) high-risk melanoma families in high baseline incidence area -- Australia, the United States, and Sweden, 2) high-risk melanoma families in low baseline incidence area -- Europe except Sweden, and 3) all melanoma families from Australia, the United States and Italy. The results will give useful information about an individual's cutaneous melanoma risk for his or her clinical decisions and for researchers to enroll high-risk individuals in genetic studies.
BayesMendel is a package for use with the freeware program R. To run BayesMendel, users should be familiar with R. An Introduction to R and other free R tutorials are available on the web. CaGene Package CaGene, by David Euhus, is a user-friendly package that can be downloaded and run on Windows. Register and download CaGene here for free.