Version 1.4-3: 1. Pancreas cancer model, PancPRO, added to the package Version 1.4-2: 1. MMRpro and brcapro prediction algorithm uses hazard function and accounts for death from other causes. 2. calc.future.risk function added. 3. make.BM.object function removed. 4. death.othercauses data set added. 5. MMRpro and brcapro output objects of class BayesMendel for use in generic plot function. Version 1.4-1: 1. Changed all referenes of 'crcapro' to 'MMRpro' 2. Incorporated a new 3-gene version of 'MMRpro', Ngene. Ngene completely replaces aveG and margene for both brcapro and MMRpro. 3. Moved parameter specification part of MMRpro to MMRparams 4. Removed 'cancerrisk' and 'summary.cancerrisk' - now incorporated into 'brcapro' 5. Note the rows and columns of the posterior probability matrix for brcapro have been switched. 6. New .Rdata files 'MMRpenet' and 'MMR.fam' replace 'HNPCCpenet.2004' and 'crca.fam'. 7. Output for brcapro and MMRpro is now in list format 8. Function 'makeBMobject' added for enabling use of generic plot function to plot pedigree structure Version 1.3-2: 1. Added generic 'plot' option to display pedigree structure and probabilities Version 1.3-1: 1. Updated penetrance estimates for breast and ovarian cancers 2. Oophorectomy history can be included in the model 3. Molecular marker information can be included in the model Version 1.2-5: 1. Fixed a typo in brcapro.R (It does not affect the calcuation though) 2. Added a patch (margenerec.c) so that BayesMendel can handle models with recessive mode of inheritance. See the help file for aveG(), which can now be specified to do recessive calculations. 3. Replace Australian.R with LAMBDA.R, use the help file for LAMBDA() for details. Version 1.2-4: 1. Fixed a bug in cancerrisk.R Version 1.2-3: 1. Updated BRCApenet.AJ.2004 and BRCApenet.nonAJ.2004 Version 1.2-2: 1. Added in MakeRelationship.R 2. Added in BRCApenet.Italian.RData, the BRCA penetrance object for the Italian population (Marroni 2004) 3. Added in Australian.R (Apicella 2003) 4. Improved the documentations Version 1.2-1: 1. Added in new BRCA penetrances for AJ and nonAJ (Chen 2004) BRCApenet.AJ.2004 BRCApenet.nonAJ.2004 2. Updated HNPCCpenetrance HNPCCpenet.2004 3. Impoved documentation for the penetrance objects Version 1.1-15: 1. Improved output description (documentation) 2. Fixed the problem with endometrial cancer in CRCAPRO ----------------------------------------------------------------------- References: Chen S, Iversen ES, Friebel Tara, Finkelstein D, Weber BL, Eisen A, Peterson LE, Schildkraut JM, Isaacs C, Peshkin BN, Corio C, Leondaridis L, Tomlinson G, Amos CI, Strong LC, Berry DA, Dutson D, Kerber R, Euhus DM, Parmigiani G. Comprehensive Evaluation of Breast and Ovarian Cancer Risks Associated with BRCA1 and BRCA2 Mutations. (in progress) 2004 Marroni, F., Aretini, P., D'Andrea, E., Caligo, M.A., Cortesi, L., Viel, A., Ricevuto, E., Montagna, M., Cipollini, G., Federico, M. et al. (2004) Penetrances of breast and ovarian cancer in a large series of families tested for BRCA1/2 mutations. Eur J Hum Genet, 12, 899-906. Apicella C, Andrews L, Hodgson SV, Fisher SA, Lewis CM, Soloman E, Tucker K, Friedlander M, Bankier A, Southey MC, Venter DJ, Hopper JL. Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2 for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA). Breast Cancer Research 5(6): R206-216. Hopper JL, Jenkins MA. Modeling the probability that Ashkenazi Jewish women carry a founder mutation in BRCA1 or BRCA2. American Journal of Human Genetics 1999, 65: 1771-1775.