Summary of Research Interests: 

My research activities focus on clinical trials.  A large fraction of my time is spent collaborating with clinical oncologists designing and analyzing studies.  In designing a clinical trial, I determine the most efficient way to answer the clinical question of interest, including how many patients should be studied, and how the trial will be conducted.  The analysis consists of applying statistical methods to determine if, for example, the new treatment helped patients survive longer than they would have on another treatment. I also work on laboratory-based studies, including the exploration of the relationship between methylation markers and cancer incidence and progression, and gene expression microarray studies.  There are numerous types of trials and studies within the Cancer Center and so the analytic methods that I use and the scientific questions I address are quite varied.

My methodologic research relates closely to my applied interests.  My primary statistical research areas of interest are in early phase studies.  Specifically, I work on methods for finding efficient dose escalation designs and on new trial designs that allow early stopping when the primary outcome of interest is time to disease progression. 

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